That pretty projectile that had such nice numbers of SD en BC and KE while resting in their box, now either meets its nemesis - or overcomes its life's one time challenge of skin and sinew and muscle and rib bone and shoulder bone and carrying on through to mechanically rip open the heart's top chambers and demolish the pulse nodes stopping oxygen to the brain, and then breaking through an opposite rib and the opposite humerus and either passing through or getting stopped in the pliant web of the opposite skin.
The principles relevant to the factors mentioned above are fully discussed here:
https://www.bullet-behavior.com/forum/totally-technical/relative-penetration-values-for-dangerous-game-cartridges